Psoriasis is a chronic and relapsing inflammation of the skin, non-contagious and non-infectious. The mechanism underlying psoriasis is immunological with the involvement of Langherans cells and T lymphocytes that produce proinflammatory cytokines with proliferation of keratinocytes and accelerated reproduction of epidermal cells.
The classic psoriasis lesion has an area of erythema (redness) with sharp edges, superimposed by white mother-of-pearl scales caused by abnormal thickening of the stratum corneum. The sites most affected by psoriasis are: elbows, knees, hands, coccyx, scalp, feet. When psoriasis is associated with joint involvement it is referred to as psoriatic arthritis.
Psoriasis is a multifactorial pathology, to which the following contribute:
· Genetic factors: psoriasis is a familial genetic predisposition. First-degree relatives of people with psoriasis have a 10 times higher risk of developing the disease.
· Environmental factors: psychogenic and emotional (bereavement, accidents), physical (wounds, trauma, injuries), drugs (NSAIDs, beta-blockers, lithium), infectious (febrile episodes, streptococcal pharyngitis in children).
Psoriasis is favored by lifestyles such as: smoking, alcohol, obesity, stress, improper diet. People with a high Body Mass Index have a higher risk of developing psoriasis.
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